Wholesale Top Quantity Best Price Monoammonium Glycyrrhizinate

English name: licorice extract

Latin Name: glycyrrhizin acid

CAS No.: 1405-86-3

Molecular Formula: C42H62O16 

Active ingredients: Glycyrrhizin, glycyrrhizic acid

Specification: glycyrrhizic acid 20%-98% by HPLC
Use Part : Root/Bark

Appearance: White crystalline powder 

Mesh size:80 Mesh

Test Method: HPLC 

In Chinese medicine, it is generally recommended to take 8-15 grams of licorice per day (as a decoction), take 100 grams of licorice during the disease, and tend to be used for respiratory, cardiovascular, endocrine and digestive system diseases. In Greek medicine, it has standard usage for the treatment of chest and respiratory diseases, but it seems to be a treatment for Edison's disease, and Chinese herbal medicine licorice is said to have enhanced performance, improved health, treatment of injury or swelling, and its detoxification. .

Equicyrin in licorice appears to have the ability to inhibit cocaine-induced dopamine release and subsequent movement (reflecting dopaminergic release), which is also mimicked by licorice methanol extract and dose-dependently by GABA effect. These results were later reproduced with orally ingested glycyrrhizin at 5 mg/kg, which appeared to reduce the exercise induction of 20 mg/kg cocaine, normalizing the phosphorylation of CREB and c-Fos by the cocaine nucleus. Licorice supplements have shown a desire to reduce addiction to dopaminergic compounds.

The ethanol extract of licorice can reduce the sleep latency (time required for falling asleep) and increase the sleep duration of the rats in a dose-dependent manner of 50-500 mg/kg, which is statistically significant at 250-500 mg/kg, and The efficacy was not significantly different from the stability of 2 mg/kg. These changes were associated with a stable and high-dose licorice that increased non-REM sleep, but not with REM sleep.

When pre-loaded with 150 mg/kg licorice extract (5.19 g dry plant extract), the decrease in latency induced by scopolamine and diazepam (indicating a decrease in cognitive ability in rats) appeared to be completely abolished; this study was conducted in Medline (Medical Information Online) Can be reproduced in the system).

Glycyrrhiza itself appears to have neuroprotective effects, and cognitive enhancement may occur by protecting exogenous toxins or cognition during decline in organic cognition.

Glycyrrhizin was tested in diabetic rats at a dose of 5-50 mg/kg to prevent cognitive decline in the type II diabetes control (evaluated by passive avoidance learning within 30 days). Glycyrrhizin appears to attenuate learning disabilities caused by exogenous toxins or decreased cognitive ability (the latter has limited evidence).

A study evaluating the neuroprotective effects of isolated glycyrrhizin on diabetic mice showed that administration of 25-50 mg/kg licorice to healthy mice enhanced learning and memory.

Cognitive improvement of licorice extracts at concentrations of 75, 150 and 300 mg/kg has been noted when these doses were administered to the control group and compared to the toxin group.

Oral administration of mice 5, 10 or 20 mg/kg of licorice for 28 days prior to swimming testing increased the swimming time by 22.58%, 43.55% and 50.04% (5, 10, 20 mg/kg) in a dose-dependent manner, which was related to exercise. The induced decrease in lactate is associated with a decrease in serum BUN (both indicating less glycolysis).

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