Baical Skullcap Root Extract Baicalein 98% Hplc/ High Quality Baicalein/Baical Skullcap Root

Baical Skullcap Root Extract Baicalein 98% Hplc/ High Quality Baicalein/Baical Skullcap Root

Type:Herbal Extract
Form:White Fine Powder
Part:Fruit
Extraction Type:Liquid-Solid Extraction
Place of Origin:Shaanxi, China (Mainland)
Brand Name:JinTai
Model Number:100% Nature
Test Method:HPLC
Function: Health Protection
Shelf life:2 Years
Application:Healthcare Products
Storage:Dry Container
Delivery Details:within 2-3 working days after confirming order
Packaging:Bottle, Can, Drum, Glass Container, Mason Jar, Plastic Container, Vacuum Packed
Baicalein 95% (HPLC) CAS No.: 491-67-8 Molecular Formula: C15H10O5 Molecular Weight: 270.24

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Product Details


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黄芩提取物 1


Active ingredient: Baicalein

Specification: 95% tested by HPLC

Appearance: Yellow needle crystal powder

CAS No.: 491-67-8

Molecular Formula: C15H10O5

Molecular Weight: 270.24


Product Introduction(1).jpg

Intracerebral injection of baicalein showed increased sedative properties of sleep time (108-120% of the control group), whereas benzodiazepine antagonists failed to eliminate this effect in one study, but in another The increase in sleep time was successfully prevented in the study. Slow wave sleep and fast sleep seem to increase when baicalin is administered before sleep in the dark phase (nighttime sleep).


In spontaneously hypertensive rats, which is also a model of attention deficits associated with altered dopamine transport, Oroxylin A appears to increase attention, which is thought to be related to its ability to block dopamine transporters.


Due to its inhibition of the dopamine transporter, Oroxylin A may have an attention-promoting property similar to methylphenidate (Ritalin).


Baicalin has been shown to stimulate nitric oxide in isolated HUVECs (endothelial cells) by activating eNOS in the range of 50-200 nM, with 50 nM being superior to 10 nM bradykinin (comparative). Baicalein, wogonin and baicalin appear to be inactive against eNOS in the range of 10-200 nM, indicating that the glucuronidyl group of baicalin is required. This may be biologically relevant as some evidence suggests that the effects of hypothermia due to vasodilation of the skin are dose dependent.


Baicalin (glycoside, aglycon inactive) appears to be a potent eNOS inducer and may increase nitric oxide. This may be relevant after oral ingestion due to the low concentration required.


The composition of Astragalus membranaceus has demonstrated a role in reducing lipid and cholesterol secondary to AMPK activation in vitro.


Intraperitoneal injection of 80 mg/kg baicalein for 16 weeks inhibited the increase in fat caused by the high-fat diet in rats, which is thought to be secondary to the activation of AMPK in the liver. In diabetic mice (db/db), 10 mg/kg or 100 mg/kg xanthine (11.02% baicalin) extract was administered daily for 4 weeks, and the supplement was able to dose-dependently reduce the observed weight gain, again It is believed to be due to AMPK activation.


There is little evidence, but isolated flavonoids or root extracts themselves do reduce weight gain, which is thought to be secondary to AMPK activation.


Astragalus membranaceus has a moderate anti-inflammatory effect on LPS-induced macrophage activation. Ethanol root extract (8.53% baicalin) reduced nitric oxide production to 8.85% of the control at 800 μg/mL and 54.6 at 200 μg/mL. % (expressed only by the combination of schizonepeta). The water extract had minimal inhibition and showed potency (50-400 μg/mL) comparable to 25 μM gallic acid elsewhere.


Baicalin is known to inhibit HIV replication with potency ranging from 43.27 to 47.34 [mu]M and is more potent when combined with zinc (29.08-31.17 [mu]M).


The antibacterial effect of baicalin on S. aureus-induced pneumonia has been noted.

Product Specification(1).jpg


Certificate of Analysis

Analysis

Specification

Results

AssayHPLC

≥95%

95.08%

Appearance

Yellow fine powder

Complies

Ash

≤5.0%

1.5%

Moisture

≤5.0%

3.2%

Heavy metals

≤10ppm

Complies

As

≤2.0ppm

Complies

Odor

Characteristic

Complies

Particle size

100%through 80 mesh

Complies

Microbioiogical

Total of bacteria

≤1000cfu/g

Complies

Fungi

≤100cfu/g

Complies

Salmgosella

Negative

Complies

Coli

Negative

Complies

Storage     Store in cool & dry place. Do not freeze.

            Keep away from strong light and heat.

Shelf life    2 years when properly stored






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