English name: Berberine Hydrochloride
Latin Name: Berberine Hydrochloride
CAS No.: 633-65-8
Active ingredients: Berberine Hydrochloride
Specification: Berberine Hydrochloride 97%
Use Part : Bark
Appearance: Yellow fine powder
Mesh size:80 Mesh
Test Method: Titration
Berberine (berberine) is a compound extracted from various herbs. It is a supplement because of its anti-diabetic effect, which is comparable to the efficacy of some drugs.
Berberine is supplemented by its anti-inflammatory and anti-diabetic effects. It also improves gut health and lowers cholesterol. Berberine can reduce the production of glucose in the liver. Human and animal studies have shown that 1500 mg of berberine is administered in three doses of 500 mg each time, as well as with 1500 mg of metformin or 4 mg of glibenclamide (two drugs for the treatment of type 2 diabetes).
Berberine can also work synergistically with antidepressants and help reduce body fat.
Berberine (2,3-methylenedioxy-9,10-dimethoxy-berberine) has been used historically as an antimicrobial, antiprotozoal and antidiarrheal agent for Ayurvedic and traditional Chinese medicine. (Substitute by herbal medicine containing it).
Berberine has been shown to be effective against various bacterial strains such as cholera, Giardia, Shigella and Salmonella; potentially also Staphylococcus, Streptococcus and Clostridium. Its effects on protozoa can be extended to Giardia lamblia, Trichomonas vaginalis, Leishmania and malaria. Surprisingly, in these antiprotozoal effects, the crude extract was more effective than the isolated berberine, indicating synergistic or additive effects with other compounds in these plants.
Berberine can pass the blood-brain barrier.
A mouse study using 5 mg/kg berberine (berberine) (injection) noted a time-dependent decrease in immobility time in the forced swim test, indicating that it has an antidepressant effect.
Berberine reduces heart tissue ischemia and may have the potential to reduce cardiac fibrosis.
Studies have shown that low-density lipoprotein cholesterol is reduced by 25% in patients with hypercholesterolemia after 3 months of taking berberine.
Berberine may inhibit lipid synthesis, secondary to activation of AMPK as a major mechanism of action.
Berberine (10-50 uM) inhibits the activity of a protein called AEBP1, which prevents macrophages from taking up oxidized LDL and attenuates foam cells (atherosclerotic deposition of macrophages) in a dose-dependent manner. The formation of matter).
The hypoglycemic effect of berberine (berberine) was first discovered in 1988. When berberine was given anti-diarrhea effect, hypoglycemic effect was occasionally noticed in diabetic patients.
A meta-analysis of berberine was performed because it involved type 2 diabetes. The meta-analysis indicated 14 trials (both from China), including 1,068 patients between 2007 and 2011, and noted that 0.5-1.5 g of berberine per day combined with lifestyle intervention for more than 12 weeks, with improved fasting blood glucose (0.87 mmol) /L reduction; CI 0.54-1.20) and postprandial blood glucose improvement (1.72mmol / L reduction; CI 1.11-2.32) and HbA1c (0.72% reduction; CI 0.47-0.97%), and improved lipid metabolism and reduction Fasting insulin levels were 0.5 mU/L; CI 0.03-0.96).
It has been shown to be highly effective against inflammatory effects, but animal models use injections; the effect of oral intake is for further study.
It may prevent macrophages from becoming foam cells, which is the result of absorbing oxidized low-density lipoproteins (with acute protection, but the foam cells themselves become plaques in the arteries over time).
Berberine (berberine) also appears to inhibit the expression of certain anti-apoptotic proteins in cancer cells, such as Mcl-1. Berberine can also affect telomerase activity through a variety of mechanisms, including by inhibiting human telomerase reverse transcriptase (an important component of human telomerase).
Another possible mechanism by which berberine is effective against cancer is through JAK3 selective inhibition, as at least one study suggests that berberine may reduce the survival of cancer cell lines that overexpress active JAK3 (Ba/F3-JAK3V674A and L540). force.
Injection of berberine into a mouse model of metastatic melanoma inhibits the formation of tumor nodules; the mechanism is through downregulation of ERK1/2-associated downregulation of matrix metalloproteinases.
In both tested colon cancer cell lines (HT-29 and IMCE) and normal cell lines (YAMC), 50 μM berberine inhibited more than half of cancer cell growth and was further inhibited at 100 μM, and these doses induced cancer Apoptosis; indicates the anticancer potential of berberine in colon cancer cells.
Berberine (berberine) induces apoptosis of breast cancer cells in vitro by 25 μM via a mitochondrial/caspase-dependent pathway.
Berberine has a fairly strong anti-fibrotic effect, comparable to chyle and TUDCA, which is quite significant because both are highly recognized liver health products.
Adding berberine for lifestyle intervention can reduce liver fat content.
Berberine (berberine) appears to be effective in breaking the adverse effects of hyperglycemia on the kidneys and is the most well studied in preventing the progression of fibrosis in diabetic nephropathy.
Norepinephrine has increased in the brain of mice after injection and oral treatment, and serum levels have not been measured.
Certificate of Analysis
Total of bacteria
Storage Store in cool & dry place. Do not freeze.
Keep away from strong light and heat.
Shelf life 2 years when properly stored
1> Applied in health product field, to help the body fight the virus;
2> Applied in cosmetics field, usually added into capsule or tablet which is used for treating vascular disease.
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