Pure Licorice Extract/Glycyrrhizin Acid/ Natural Glycyrrhizinic Acid 80% Licorice Root Extract

Pure Licorice Extract/Glycyrrhizin Acid/ Natural Glycyrrhizinic Acid 80% Licorice Root Extract

Type: Glycyrrhizinic
Form: Powder
Part: Bark
Extraction Type: Solvent Extraction
Packaging: Drum, Glass Container, Plastic Container, Vacuum Packed
Place of Origin: Shaanxi, China (Mainland)
Grade: AAAAA
Brand Name: JT
Model Number: Glycyrrhizinic
Keyword: Glycyrrhizinic
Test Method: UV/HPLC
Appearance: White powder
Moisture: ≤5.0%
Particle size: 100%through 80 mesh
Total of bacteria: ≤1000cfu/g
Package: 1kg/bag or 25kg/drum
Shelf life: 2 years

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Product Details

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甘草



English name: licorice extract
Latin Name: Glycyrrhizic acid

Active ingredients: glycyrrhizin acid
Specification: glycyrrhizic acid 20%-98%

Appearance: White crystalline powder 



 


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Licorice flavonoids reduce intestinal lipid absorption (which may be the basis for anti-obesity).


Taking 100g of licorice (150mg glycyrrhetinic acid) can raise blood pressure, blood pressure is increased by 3.5mmHg in normal blood pressure, blood pressure is increased by 15.3mmHg at baseline (laboratory measurement), blood pressure is more obvious, and still in 24-hour dynamic measurement It is statistically significant. Later studies using 500 mg of glycyrrhetinic acid indicated that cortisol increased in normal blood pressure and hypertensive patients, while systemic activity of 11βHSD2 did not differ between the two groups. Regardless of 11βHSD2 inhibition, cortisol does not appear to mediate blood flow sharply (as assessed by forearm vascular resistance).


For ApoE-/- mice, isolated light licorice in 20 mcg or 200 mg licorice ethanol extract was able to reduce LDL oxidation after 6 weeks of consumption, and when administered to a small sample of human subjects (n = 10), each After a daily intake of 100 mg of alcohol licorice extract for 2 weeks, it was noted that when LDL was extracted from their serum and then tested in vitro after 2 weeks, the subject's LDL was significantly protected from copper-induced oxidation. 6 months of consumption of licorice root (60mg LicoLifeTM gives 5mg of light licorice) can reduce LDL oxidation in humans by 20%. Glycyrrhizin appears to be the most potent polyphenol-protective LDL from licorice oxidation and has similar potency to quercetin.


Glycyrrhizin appears to be secondary to anti-inflammatory effects, which can reduce the secretion of cell adhesion factors (ICAM-1, VCAM-1 and E-Selectin), which may reduce the adhesion of immune cells to the endothelium, such as 3uM and 10uM in vitro. Glycyrrhizin inhibits 46% and 65% of monocyte binding.


Some anti-atherosclerotic effects of glycyrrhizin appear to be mediated by anti-inflammatory effects and the immune system. A study evaluating monocytes (immune cells that cause atherosclerosis) suggests that Cyclocarrisin can reverse glucose-induced PON2 decline (and estradiol that may be mediated by estrogen receptors) and retained Mn- Superoxide dismutase and catalase levels.


In vitro, light licorice (flavonoids from licorice) appears to interfere with the transcription of PPARγ and CCAAT binding proteins and reduce lipogenesis in differentiated adipocytes, observed in 18β-glycyrrhetinic preadipocytes. Similar anti-adipogenic effects, 5-40 uM secondary to down-regulation of PPARγ and inhibition of Akt. Other studies have shown that the anti-obesity effect of 2% licorice oil (LFO; 1% glycyrrhizin content) (weight loss over time) has been noted that the reduction in fat mass is accompanied by a decrease in hepatic triglycerides, which is considered This is due to a decrease in mRNA (79.9%, 52.2%, and 64.8%) of ACCα, FAS, and SREBP-1c within 21 days, and an increase in PPARα mRNA (134.8%). A reduction in liver fat formation genes has been noted elsewhere, with 2% of LFO in rats.


There may be an unknown association with anti-obesity mechanisms, but it appears to be associated with interference with PPARγ, a lipogenic gene, or a corresponding decrease in calorie formation in the liver.




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Certificate of Analysis

Analysis

Specification

Results

AssayHPLC

7.5%

7.53%

Appearance

Brown fine powder

Complies

Ash

12%

8.37%

Moisture

10%

7.59%

Pesticides

2ppm

Complies

Heavy metals

20ppm

Complies

Insoluble matter in water

5%

3.3%

Odor

Characteristic

Complies

Particle size

100% through 80 mesh

Complies

Microbioiogical

Total of bacteria

≤1000cfu/g

Complies

Fungi

≤100cfu/g

Complies

Salmgosella

Negative

Complies

Coli

Negative

Complies

Storage     Store in cool & dry place. Do not freeze.

            Keep away from strong light and heat.

Shelf life    2 years when properly stored


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