High Purity Piperine 98% Water-soluble Black Pepper Extract/ High Quality Black Pepper Extract

High Purity Piperine 98% Water-soluble Black Pepper Extract/ High Quality Black Pepper Extract

Type:Herbal Extract
Form:White Fine Powder
Place of Origin:Shaanxi, China (Mainland)
Brand Name:JinTai
Model Number:100% Nature
Specification:90%~98% Piperine
Test Method:HPLC
Function: Health Protection
Shelf life:2 Years
Application:Healthcare Products
Storage:Dry Container
Delivery Details:within 2-3 working days after confirming order
Packaging:Bottle, Can, Drum, Glass Container, Mason Jar, Plastic Container, Vacuum Packed

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Product Details


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三氯蔗糖

Botanical Name  Piper nigrum L.

Part Used  Fruit

Specification  90%~98% Piperine

Test method  HPLC

CAS#:94-62-2

Molecular formula: C17H19NO3 

Molecular weight: 285.34

Appearance: Brown Fine Powder 



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Certain ingredients in the diet can affect drug metabolism and transport and alter the distribution of the drug in the body. Piperine inhibits drug metabolism enzymes in rodents and increases certain drugs in the human body (including P-glycoprotein substrates phenytoin and rifampicin) The plasma concentration inhibits the transport of digoxin and cyclosporine A on Caco-2 cells; piperine inhibits the drug transporter P-glycoprotein and the drug-metabolizing enzyme CYP3A4, both of which are mainly in intestinal epithelial cells and Hepatocyte expression is the first place for many drugs to be eliminated. Therefore, piperine in food affects the blood concentration of P-glycoprotein and CYP3A4 substrate, especially when taking these drugs orally.

The combination of piperine and nimesulide increases the bioavailability of nimesulide, achieves a better therapeutic index, enhances antinociceptive pain and anti-inflammatory effects, and reduces the frequency of side effects of nimesulide when used alone. The combination of piperine significantly increased the bioavailability of the beta lactam antibiotics amoxicillin and cefotaxime sodium in rats, probably because of the action of piperine on microsomal metabolic enzymes or enzyme systems. In the intravenous injection of phenytoin, the elimination phase of phenytoin was significantly changed in rodents exposed to piperine, and the elimination of phenytoin was also delayed in volunteers taking piperine.

The mechanism by which piperine increases bioavailability is unclear, presumably related to changes in membrane lipid dynamics and the configuration of certain enzymes in the gut, increasing absorption. Piperine increases membrane fluidity and alters enzyme kinetics. Due to the interaction of the non-polar portion of piperine with the lipid and hydrophobic portions of the protein, membrane lipids are reduced as a support for the enzyme protein, thus altering the conformation of the enzyme. Structural studies have shown that piperine increases the length of the endoplasmic reticulum microvilli in intestinal epithelial cells. The authors believe that piperine can induce changes in membrane kinetics and membrane permeation properties, and induce protein synthesis associated with cell scaffold function, resulting in increased intestinal absorption area, assisting substances to effectively penetrate the epithelial cell barrier.

1.As pharmaceutical raw materials for arthritis, rheumatism, anti-inflammation, detumescence and so on, it is mainly used in pharmaceutical field;

2.As products effective ingredients for improving blood circulation and soothing the nerves, it is mainly used in health product industry;

3.As active ingredients of skin care products, it is mainly used in cosmetic industry.

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Certificate of Analysis

Analysis

Specification

Results

AssayHPLC

≥98%

98.3%

Appearance

White fine powder

Complies

Ash

≤5.0%

0.8%

Moisture

≤5.0%

1.2%

Heavy metals

≤10ppm

Complies

Pb

≤2.0ppm

Complies

As

≤2.0ppm

Complies

Odor

Characteristic

Complies

Particle size

100%through 80 mesh

Complies

Bulk Density

45-60g/100ml

Complies

Solvent Residue

Eur.Pharm

Complies

Microbioiogical

Total of bacteria

≤1000cfu/g

Complies

Fungi

≤100cfu/g

Complies

Salmgosella

Negative

Complies

Coli

Negative

Complies

Storage     Store in cool & dry place. Do not freeze.

            Keep away from strong light and heat.

Shelf life    2 years when properly stored


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