Product name:Polygonum Cuspidatum Extract
Extract Part: Fruit
Extraction Type: Water/Enthanol
Particle size: 100% 80 mesh
Brand Name: JT
Place of Origin: Shaanxi, China (Mainland)
Japanese knotweed or knotweed is a traditional Chinese medicine for circulation and heart health. It is a good source of resveratrol, and most of the benefits of Japanese knotweed may actually be the benefits of resveratrol.
Polygonum cuspidatum is one of the most commonly known plants of the Japanese knotweed. This plant is an invasive species traditionally used in traditional Chinese medicine and Japanese medicine because it is beneficial to gastrointestinal health and circulatory health (in some other places it is claimed to have cancer prevention).
Most of the effects of Japanese knotweed can be traced back to steroids (resveratrol) or steroids (emodin) for circulatory and gastrointestinal benefits, respectively.
Polygonum cuspidatum is a herbaceous plant of the family Polygonaceae. It is native to eastern China and Japan, and Polygonum cuspidatum has traditionally been used to treat atherosclerosis as well as cancer, asthma, high blood pressure and cough.
The retinol contained in Polygonum cuspidatum can prevent colon cancer.
A human study using Japanese knotweed found that after 6 weeks of supplementation with 200 mg (40 mg resveratrol) per day, the extracted immune cells had a 25% less NF-kB translocation. NF-kB is an inflammatory mediator that reduces inflammation overall. A decrease in NF-kB activity results in less circulating inflammatory cytokines of TNF-[alpha] and IL-6. Large doses in animals (100-200 mg/kg ethyl acetate fraction) have been shown to induce acute anti-inflammatory effects and show promise in animal models of rheumatoid arthritis.
Naphthoquinone from Polygonum cuspidatum has been shown to be a potent HRV 3C protease inhibitor with an IC50 of 4.6 uM. This enzyme is required for the replication of rhinoviruses, the most common drug for the common cold. Inhibitors are therefore being studied to reduce the incidence and severity of the common cold.
Naphthoquinone in Japanese knotweed also showed protective effects in vitro after its antioxidant action. Oxidative damage was completely eliminated, and at the higher concentrations tested (2.5 uM, 5 uM), the increase in cell viability actually exceeded the control.
Emodin has been shown to protect neurons from damage in vitro, but due to the lower bioavailability of emodin, these results may not be relevant to the actual situation.
Despite the high doses required to show neuroprotection (20 mg/kg resveratrol, 12.5 mg/kg polymorphic protein), there appears to be a variety of neuroprotective compounds; and among the more potent compounds are currently unknown.
In a study of 32 Chinese traditional plants, Japanese knotweed was found to have the strongest EC50 value of 6.4 ug/mL. The active molecules behind this estrogenic effect may be strontium content, although they appear to inhibit the binding of 17β-estradiol to its receptor when acting together, and can act as agonists (during estrogen deficiency) and competitive antagonism The agent (during excess estrogen) works. However, emodin (the most prominent sputum) had an EC50 of 10.1 +/- 0.36 ng/mL, while the entire knotweed was more effective at 6.4 ug/mL. This indicates the presence of another compound with potent estrogenic effects. A study that segmented fragments of Brassica found that emodin (Hzs1) fragments matched fragments that did not contain emodin (Hzs6), which is responsible for unknown compounds.
Japanese knotweed has been proven to penetrate the skin, so it has been used as a cosmetic for topical application.
When tested in melanocytes (melanin-producing cells under the skin), the component of the knotweed, known as spruce, inhibits tyrosinase activity in a dose-dependent manner and can be used as a skin whitener. Spruce chinensis does not act directly on potent inhibitors of tyrosinase, but appears to inhibit tyrosinase mRNA and subsequent protein content. Resveratrol also has an indirect inhibitory mechanism because resveratrol is a substrate for tyrosinase, and its metabolites then accumulate and inhibit activity. Paclitaxel is also a component of Japanese knotweed, which inhibits melanogenesis by the antioxidant action of tyrosinase, and, like spruce, can down-regulate melanin content. Emodin and guanidine can directly inhibit tyrosinase activity, although the related emodin-methyl ether is more effective and has a skin permeability of 48 times or more.
In addition to whitening, Japanese knotweed has been shown to accelerate wound healing in rats and enhance the quality of wound repair relative to untreated controls. When applied topically, the anti-inflammatory effect of Polygonum cuspidatum also appeared, mainly due to the content of trans-resveratrol.
Certificate of Analysis
White fine powder
100%through 80 mesh
Total of bacteria
Storage Store in cool & dry place. Do not freeze.
Keep away from strong light and heat.
Shelf life 2 years when properly stored
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