[Botanical Name] Cnidium Monnieri (L. ) Cuss
[Part Used] Fruit
[Active Ingredients] Osthole
[CAS No. ] 484-12-8
[Molecular Formula] C15H16O3
[Molecular Weight] 244.29
[Appearance] Greenish Yellow or white fine powder
[Test Method] HPLC
An erect herb from Chinese medicine. Cnidium and its main bioactive agent (called osthole) appear to have a similar mechanism to Viagra in penile tissue and hippocampus; the effects of Cnidium on testosterone and cognition remain unexplored.
Cnidium fruit is traditionally used for antiviral properties, rash, erectile agents (male) and gynecological health (female), anti-osteoporosis and anti-diabetes, and sometimes anti-inflammatory.
Cnidium can reduce alcohol-induced fatty liver; in one study, mice consumed alcohol for 52 weeks with 52% calorie intake, followed by 10-40 mg/kg osthole for 6 weeks, and osthole normalized CPT1A And changes in CYP2E1 transcription rate (due to long-term alcohol intake and contribute to further fat accumulation) and can reduce liver fat content in a restorative manner. These effects are also seen when the same dose of Cnidium is ingested and attributed to antioxidants and anti-inflammatory mechanisms.
Benefits can also be seen in diet-induced fatty liver, especially in milk fat-induced fatty liver. The above mechanism for the activation of PPARα in alcohol-induced fatty liver is also seen in dietary fat-induced fatty liver (NAFLD). Then, activation of PPARα can subsequently down-regulate DGAT and CYP7A1, which abnormally elevated fatty liver during the period and increased CPT1A activity. This is suppressed during fatty liver.
In vitro studies of MCF-7 and MDA-MB-231 cell lines suggest that osthole can inhibit breast cancer cell proliferation with IC50 values of 25.8 uM and 30.2 uM, respectively.
In vitro, osthole also observed inhibition of MMP2, which helps explain how osthole inhibits invasion and metastasis of breast cancer cells. This ability may be related to FASN inhibition, as cells overexpressing HER2 are generally considered to be more prone to metastasis.
Although osthole (from Cnidium) is thought to reduce the effects of diabetes on AMPK activators, a reduction in fatty liver may also contribute to the anti-diabetic effect.
Osthole exhibits non-selective cytotoxicity in cancer cells, particularly for breast cancer (MCF-7), lung cancer (SK-LU-1), skin cancer (KB), and liver cancer (HepG2).
Certificate of Analysis
Brown yellow fine powder
100%through 80 mesh
Total of bacteria
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