Latin Name: Gynostemma pentaphyllum
CAS No.: 15588-68-8
Molecular forula: C47H80O17
Molecular Weight: 1062.32
Active ingredients: Gypenosides
Use Part: Stems & leaves
Appearance: Light yellow powder
Mesh size: 80 Mesh
Test Method: UV
Gynostemma pentaphyllum is a ginseng herb.
Sometimes referred to as "Southern ginseng" or "cheap ginseng" because it is used as a cheap substitute for ginseng, or as a ginseng adulteration, sold at normal prices to reduce costs. Surprisingly, Gynostemma pentaphyllum has a good ginsenoside content, which was once thought to be ginseng-owned. Therefore, the biological effects of Gynostemma pentaphyllum and ginseng seem to be very similar, but Gynostemma pentaphyllum is likely to be more anti-diabetic (due to the specific Gynostemma pentaphyllum in Gynostemma pentaphyllum).
The current limited body research is focused on trying to portray a large number of Gynostemma total glycosides in this herb to see which ones can be considered "active" compounds. Currently, we have two human studies showing that tea made from Gynostemma pentaphyllum can be used with standard anti-diabetic treatments and enhance its efficacy over time (called adjuvant therapy).
This herb has also been promoted to have anti-aging and longevity effects, but has not been studied. In addition, anticancer effects are still at the beginning of the study, but these effects appear to be very similar in many cell lines.
In general, this is a more anti-diabetic ginseng; the disadvantage is that other benefits associated with ginseng (mental health, cognitive enhancement, anti-fatigue) have not been properly assessed with Gynostemma pentaphyllum.
Gynostemma pentaphyllum is a traditional Chinese medicine plant used to treat cough, wheezing, chronic bronchitis and infectious hepatitis. It appears to have ginsenoside-like saponins, although it has nothing to do with ginseng (true ginseng). Tea containing higher levels of ginsenosides is sweeter (which makes it quite popular). It is considered to be a long-lived herb and is known as an immortal herb in Gynostemma.
It appears that the protection of neurons involved in Parkinson's disease is likely to be mediated through antioxidants. Although there was no human study, it showed efficacy in relatively low doses of mice.
In vitro studies have found that the protective effect of 100-400 mcg/mL Gynostemma total saponin on glutamate toxicity is considered to be a secondary effect of the increase in glutathione depletion of γ-GCS and GR mRNA.
In the rat cognitive impairment model (BCCAO), rats were injected with 100 mg/kg or 200 mg/kg of Gynostemma pentaphyllum 61 days after surgery and assessed by the Morris water maze task (assessment of memory formation and retention), noting that only higher Dose is associated with improved memory formation following injury and is the only dose associated with improved superoxide dismutase (SOD), lipid peroxidation (MDA), and histological assessment.
The specific Gynostemma pentaphyllum known as TN-2 at a dose of 10-40 mg/kg showed a range of 40-96% inhibition of scopolamine-induced learning deficits, with 20 mg/kg being most effective.
Gynostemma total saponins from southern ginseng appear to induce endothelium-dependent vasodilation and are blocked by L-NAME and are therefore mediated through the NO-cGMP pathway. In cultured endothelial cells, incubation with 50 mcg/mL mixed Gynostemma total saponins increased the level of nitric oxide to 435 +/- 38.2% of the control by adding A23187 calcium ionophore and attenuating with indomethacin Enhanced.
It is possible to reduce vascular adhesion factors by PPARa, which may indirectly reduce atherosclerosis by preventing adhesion of immune cells to the arterial wall. Obese rats were given a study of 150-250 mg/kg Gynostemma pentaphyllum (90% Gynostemma total saponin) for 5 weeks. In both groups, the degree of triglyceride reduction was up to 35% at 5 weeks. Total cholesterol decreased in the range of 13-22%, while LDL-C decreased (HDL-C was unaffected).
Post-prandial triglycerides appeared to improve after 5 weeks of the test meal supplemented with Gynostemma pentaphyllum. These hypolipidemic effects may also have an acute effect, as a study using P407 (a lipoprotein lipase inhibitor that causes an acute peak of triglycerides), preloaded with 250 mg/kg of Gynostemma total saponins for 4 days, is capable of triglycerides The peak in the decrease was 53% (total cholesterol was reduced by 10% and HDL was unaffected), but a more significant effect was observed after 14 days (the P407 induced increase was reduced by 85%). This is thought to attenuate the effect of P407 on the LPL enzyme, and the isolated Gynostemma pentaphyllum has no effect on the LPL receptor between 5-100 ug/mL.
Certificate of Analysis
Yellow brown powder
100%through 80 mesh
Total of bacteria
Storage Store in cool & dry place. Do not freeze.
Keep away from strong light and heat.
Shelf life 2 years when properly stored
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