English name: red clover extract
Latin Name: Trifolium pratense L
CAS No.: 977150-97-2
Molecular forula: C22H18O12
Molecular Weight: 474.37
Active ingredients: Isoflavones
Specification: 2.5% 8% 20% 40%
Use Part: Aerial parts
Mesh size: 80 Mesh
Test Method: HPLC
Red clover extract (red clover extract) is isoflavones, including small amounts of soy isoflavones and some similar structures, such as Biochanin A; used as a treatment for menopause, red clover seems to have improved health and reduced hot flashes Tiny and unreliable benefits.
One study used red clover extract 398 mg (120 mg isoflavones) once a day in postmenopausal women, noting that supplements were associated with reduced anxiety after one year, but not after three months, and that other menopausal symptoms did not improve.
The formononetin extract in red clover has an impact on the cognitive ability (visual spatial reasoning) of postmenopausal women.
Supplementation with 40-80 mg of red clover isoflavones in other healthy postmenopausal women can improve arterial compliance by up to 23% by ultrasound assessment, and there is no change in blood pressure in this condition. Subsequently expanded and re-measured arterial stiffness, red clover isoflavones again reduced stiffness (as assessed by arterial compliance and pulse wave velocity) and had no effect on blood flow (through blood flow-mediated vasodilation assessment) ), there is no blood pressure effect. However, one study showed an increase in blood flow, using 50 mg of isoflavones from red clover (mainly formononetin) to treat postmenopausal women with type 2 diabetes, which coincided with a drop in blood pressure.
Arterial compliance (reactivity) may increase and may reduce the risk of cardiovascular complications, but this appears to be independent of any changes in blood flow and pressure, but seems to be related to lowering arterial stiffness; the mechanisms behind it are unclear.
There have been some positive studies using red clover supplements, but usually low-quality trials, or lack of placebo control, and only one study used blinding, noting an increase in HDL-C (18.1%). When a well-controlled positive study was observed, a one-year treatment was given in other healthy postmenopausal women, 40 mg of isoflavones were given once a day, and a 21% increase in HDL-C was noted within three months, with a one-year supplement. Another study (noticing an increase in HDL-C) noted an improvement in LDL and total cholesterol only in overweight postmenopausal women.
Biotin A appears to dock directly on MLK3 and prevents it from mediated the inflammatory response of UV radiation to skin inflammation. It has been noted that biotin A has melanin-inhibiting properties in the range of 11-22 μM by inhibiting melanogenesis in B16 cells in vitro, normalizing melanogenesis to control levels and equivalent to 400 μM arbutin. This potency was not associated with tyrosinase inhibition (partially related only at 22 μM) and replicated together with formononetin. Both Biochanin A and formononetin exhibit decolorization characteristics in vitro, 88-176 μM is equivalent to 400 μM arbutin, and when tested in mice, topical application of 2% biotin twice daily during the week A cream shows skin whitening properties. It appears to have skin whitening properties when tested in vitro and in mice, and it appears to have considerable efficacy based on its limited evidence.
Oral intake of 80 mg of red clover isoflavones for 90 days per day appears to be associated with a subjective assessment of improved skin quality (water content, texture and overall condition, as assessed by the VAS scale 0-100). Although the variability was large, the overall improvement was 17.7-18.6 points (0-100 points), while placebo increased by 5.0-6.2 points.
Supplementation with 80 mg of red clover isoflavones appears to reduce postmenopausal symptoms after 90 days, a 78% reduction by Kupperman index, and a 23% reduction of placebo over the same time period. The same structured study used 80 mg of isoflavones to note and comfort. Compared with the agent, the Kupperman index assessed a reduction in menopausal symptoms (75.4%) as well as hot flashes and night sweats (72.2-73.5%), and no such benefit was observed three months after the withdrawal.
Certificate of Analysis
Brown fine powder
100% through 80 mesh
Total of bacteria
To learn more of FAQ，please click here
To learn more about us,please click here