Natural Tribulus Terrestris Extract /Tribulus Saponins/Tribulus terrestris saponins standardized extract

Natural Tribulus Terrestris Extract /Tribulus Saponins/Tribulus terrestris saponins standardized extract

Product name Tribulus Terrestris Extract
Appearance Brown fine powder
Odor Characteristic
Using Part Overground
Active Ingredient Saponins
Product Content 10%-98%
Test Method UV
Type of extraction Solvent extraction
Package 25kg/Drum 1kg/Foil bag or By your requirement

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Product Details

Product Details(1).jpg


tribulus terrestris (1)Product name:tribulus terrestris extract


Extraction Type: Water/Enthanol

Particle size: 100% 80 mesh

Grade: Natural

Brand Name: JT

Place of Origin: Shaanxi, China (Mainland)


Product Introduction(1).jpg

Hedgehog is a plant from Ayurveda and Chinese medicine, whose roots and fruits are used for male fertility and general vitality, respectively. The roots enhance sexual desire and sexual pleasure, but do not affect testosterone, and the fruit seems to have a strong protective organ function.


Hedgehog, mainly used for men's health, especially for cardiovascular and genitourinary health. It is a common supplement to its libido-enhancing properties and putative testosterone-promoting properties.


In terms of sex, the hedgehog appears to be a relatively reliable and effective libido enhancer in rats, and a separate human study evaluating this confirms an increase in sexual health and erectile function. Although it is not known exactly how the hedgehog works, it is known that enhancing the androgen receptor density in the brain (unconfirmed muscle tissue) enhances the libido-enhancing properties of androgens.


Hedgehog is an annual herb widely distributed in China and East Asia and extends to West Asia and southern Europe. The results of this plant have been used in traditional Chinese medicine for the treatment of eye diseases, edema, bloating, high blood pressure and cardiovascular disease. In India, its use in Ayurveda is for impotence, loss of appetite, jaundice, genitourinary diseases and cardiovascular disease. In Ayurvedic medicine, hedgehogs are used to treat low back pain, sciatica, pelvic and ankle inflammation, dry cough, and respiratory diseases.


At least one study has shown that hedgehogs may have pain-reducing properties (based on traditional usage in Iran and surrounding areas). In this study, mice were subjected to chemical and thermal pain tests (formalin and appendix, respectively) and tested by injection at different doses (50, 100, 200, 400, and 800 mg/kg). The kg hedgehog extract appears to be the most effective and tends to reduce pain more than 2.5 mg/kg morphine.


In diabetic rats, 100-300 mg/kg of water extract within 8 weeks is able to prevent hyperalgesia (more sensitive to pain) caused by diabetes, and its caloric and chemical tests are equivalent to 100 mg/kg of pregabalin.


Hedgehog appears to have an antidepressant effect in stressed rats, indicating that it is an adaptation to the original herb. Its effectiveness is considerable, although this requires very high doses.


Astragalus saponin (100 mg/L) was able to reduce the infarct size in the heart exposed to ischemia/reperfusion and in vitro oxidation (infarct size was reduced to 20.24-30.32% of the control group).


Due to the activation of the protein kinase Cε (PKCε), staurosporin protects cardiomyocytes from cell death. This occurs at very low concentrations and may be associated with oral supplementation of hedgehog.


Hedgehog has ACE inhibition properties in vitro. In rats (spontaneous hypertension 2K1C), a 10 mg/kg lyophilized fruit extract appeared to lower blood pressure and correct ACE above normal levels.


A study using 2g/kg hedgehog in a streptozotocin-induced diabetes model showed that it is as effective as 10 mg/kg glibenclamide in normalizing a serum liver enzyme (AST) and is capable of More effective ALT and serum creatinine are normalized. According to the assessment of histological examination, this may be a secondary factor in preventing liver damage.


In diabetic rats, 50 mg/kg hydroalcoholic extract (45.84% saponin) for 8 weeks can improve insulin levels in serum, which is comparable to 6 mg/kg olmesartan, but the effect is slightly lower than 1 mg/kg. Lemicarbazone.


In the rat cadmium toxicity model, 5 weeks oral administration of 5 mg/kg ethanol extract of Robinia pseudoacacia can completely normalize the oxidation parameters (TBARS and antioxidant enzymes) and significantly reduce the accumulation of cadmium in the kidney within 6 weeks. 75mg/kg vitamin E is comparable.


In studies of rodents with experimental heavy metal toxicity, hedgehogs appear to have considerable protective effects that exceed the equivalent amount of vitamin E. The concentration that occurs in this case is low enough and may be suitable for human body supplementation.


Although possible renal toxicity could not be ruled out, there appeared to be little concern because the case study failed to produce a causal relationship with the herb, and individual rat intervention also noted improvements in renal function and "altered" histology. A 60 kDa protein found in hedgehogs seems to be able to dissolve calcium oxalate kidney stones in vitro, which is comparable in potency to cystine. The basic water extract of the hedgehog fruit itself also exhibits this property, with 25-100 μg/mL inhibiting the in vitro calcification of calcium oxalate with 71% inhibition while preventing between 25 μg/mL (18%) and 1000 μg. The dose dependence of stone growth.


When the hedgehog itself is used in rats, it has the most potent dose-dependent protection in ethanol extracts, and when using Unex in kidney-calculated rat models of ethylene glycol, 200 mg/kg oral intake can Reduces the formation of kidney stones, which is comparable to 750 mg/kg of cystine (it seems less potent than 400 mg/kg Unex).


A variety of other animal models have demonstrated aphrodisiac effects, including 50 mg/kg and 100 mg/kg of lyophilized extract dried fruit found in male rats with stagnation, with dose-dependent all sexual behavior and penile function parameters with long-term administration Increase in sex. Hedgehog was ingested at lower doses of 2.5, 5, and 10 mg/kg for 8 weeks, associated with reduced latency of crawling, insertion, and ejaculation, while improving crawling and insertion frequency.


Among men with a small sperm count, supplementation of 6g of hedgehog roots was associated with a significant improvement in sexual health (through survey evaluation), an increase of 49.38%, which was higher than 27.80% of placebo.


An increase in erectile properties has been noted in rabbits given 2.5-100 mg/kg of locust fruit extract for one month, and it has been noted that this dose range can enhance the efficacy of the pre-erectile signaling molecule (acetylcholine or electrical stimulation). Does not affect anti-erectile signaling molecules. The original diosgenin itself is ineffective and the same dosage range in rats appears to increase the intracavernous pressure (ICP) of the penis by 17-43% during erection (maximum efficacy is 5 mg/kg).


The hedgehog appears to relax the penile tissue in vitro and enhance the erection after oral ingestion, but the difference in dose (higher in vitro but lower in oral dose) suggests that different mechanisms are at work. The mechanism by which hedgehogs increase erection is unclear, but may be related to central androgen receptors.


High doses of hedgehogs may have the ability to induce hair pigmentation. It may have the ability to induce hair follicle staining at high concentrations.


Hedgehog fruit can prevent UVB-induced skin cell death at a concentration of 50 μg/mL in 70% ethanol extract, reducing 87.9% apoptosis to 25.5%. Studies have shown that the hedgehog fruit appears to increase DNA repair in skin cells exposed to radiation, and this does not occur in cancer cells.


In people with high blood pressure, 2 g of water extract of Robinia pseudoacacia was given within 4 weeks, and it was noted that the systolic blood pressure decreased significantly (4-4.3%) after one week, and increased to 9.6-10.7% after four weeks; diastolic blood pressure after four weeks. Reduced by 7.4-8.1%. This study should be treated with caution because the intervention group had a significant increase in blood pressure at baseline, which may amplify the hypotensive outcome.


It has been noted that the water extract of Robinia pseudoacacia has an anti-inflammatory effect in vitro, which inhibits the growth of HepG2 tumor cells (and has no effect on normal cell growth), and is thought to be secondary to increasing IκBα content and decreasing NF-kB content, the former seems to This is achieved by inhibition of IκBα kinase (although it does not affect the binding of the IKK-β subunit, usually associated with NF-kB).


Product Specification(1).jpg


Certificate of Analysis

Analysis

Specification

Results

AssayUV

total saponins≥40%

41.53%

Appearance

Yellow-Brown fine powder

Complies

Ash

≤5.0%

2.3%

Moisture

≤5.0%

3.5%

Pesticides

Negative

Complies

Heavy metals

≤10ppm

Complies

As

≤2.0ppm

Complies

Odor

Characteristic

Complies

Particle size

100% through 80 mesh

Complies

Microbioiogical

Total of bacteria

≤10000cfu/g

Complies

Fungi

≤100cfu/g

Complies

Salmgosella

Negative

Complies

Coli

Negative

Complies

Storage     Store in cool & dry place. Do not freeze.

            Keep away from strong light and heat.

Shelf life    2 years when properly stored

Application(1).jpg

1) Applied in food field, it's used as food additive with the function of lengthening life.
2) Applied in pharmaceutical field, it is frequently used as medicine supplement or OTCs ingredients and owns good efficacy for treatment of cancer and cardio-cerebrovascular disease.
3) Applied in cosmetics field, it can delay aging and prevent UV radiation.


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